Neuroimaging Core Overview

The Neuroimaging Core will serves the goals of the Center by providing support for the facilities ans methods used to conduct human brain imaging and electrophysiology experiments. Projects 1-4 of the proposed Center all use MRI/fMRI/MR spectroscopy. The Neuroimaging Core will be a central resource for educational, technical, and experimental design assistance as well as MR methods development for Projects 1-4. The Neuroimaging Core will provide support in the following ways:

  1. Providing use of the 3T magnetic resonance imaging (MRI) scanner at Princeton University and supporting all magnetic resonance imaging and spectroscopy experiments relevant to Projects 1-3.
  2. Training in basic anatomic / functional MRI (fMRI) and spectroscopy methods relevant to Projects 1-4.
  3. Consultation in the choice of pulse sequences including protocol parameter selection and other aspects of experimental design for Projects 1-4.
  4. Implementation of new MR methods (including high resolution spectroscopy, DTI-based fiber tracking, high resolution fMRI, primate MRI/fMRI development, and susceptibility artifact reduction methods), and their interfacing with other modalities used by Projects 1-4.
  5. Assisting the Computational Core with processing, analyzing, and archiving of data.
  6. Maintaining and upgrading the MRI scanner and experimental support equipment.
  7. Providing use of the Cognitive Electrophysiology facility at Princeton University and supporting EEG experiments proposed in Project 1.

These aims will be supported by the Neuroimaging Core Director, a Ph.D. level MR physicist at Princeton University with experience in MRI/fMRI/spectroscopy methods and applications. She will be assisted in these efforts by a faculty member in the Chemistry Department, an M.S. level MR engineer, and an RF/electronics technician. The EEG studies proposed in Project 1 will be supported by the EEG facility at Princeton University through the guidance of its director, a Ph.D. level EEG research scientist, and an EEG technician.

Administrative Core Overview

The Administrative Core (Jonathan Cohen, Director) will coordinate Center logistical activities and oversee fiscal and reporting functions. The administrative core is crucial to the functioning of the Center. It will oversee operations of the Neuroimaging Core and the Computational Core. The Core will promote scientific interactions among projects, facilitate meetings among scientists at different sites, provide logistical support, help prepare reports and publications and be responsible for bookkeeping and fiscal reporting.

One of the primary activities of the Administrative Core will be the coordination of meetings including the Annual Conference of the Project PIs in Princeton at which project progress and results are reviewed and plans are discussed how to best integrate results from each project into other relevant projects.

A second critical responsibility of the Administrative Core will be to coordinate and oversee activities relating to the Center's Educational Initiative. The Center will provide training for graduate students and postdoctoral fellows at each of the participating institutions through invitations to meetings, collaborations and the Annual Conference. In addition, the Center organizes an annual training program for graduate students, postdoctorals, research assistants and other individuals interested in the work of the Center and the area of cognitive neuroscience. The Administrative Core will also coordinate the activities relating to the NRSA Institutional Training Grant. Under the training grant, a curriculum of study and research experience has been designed to provide high quality research training and a close collaboration with the Center to graduate students and postdoctoral fellows.

A third principal function is to maintain the Center's Website www.csbmb.princeton.edu/ Center-related publications, and made available for download in compliance with current publishing standards. In addition, the Center maintains a series of Technical Reports, that are also available for download.

Computational Core Overview

The Computational Core will serve the Conte Center in five primary ways:

  1. It will provide access to a recently upgraded computing facility, which includes a compute cluster consisting of 64 dual-processor nodes, a dedicated file server with 9 TB of storage, a tape backup system, and a high speed network. All projects involve either computationally intensive analyses of large datasets or mathematical model simulations, so they will benefit directly from the powerful, new computing resources available.
  2. It will also provide access to a wide range of general-purpose software (used by all projects), dedicated neuroimaging data analysis packages (projects 1, 2, 3 and 4) and mathematical simulation environments (projects 3 and 6). Customized software development services will be available for specific project needs as well.
  3. The Computational Core will provide a flexible, easy to use, and secure platform for sharing data, which will facilitate the exchange of datasets between projects. All projects, having investigators located at four different sites, will benefit from a robust data sharing initiative.
  4. It will provide new data analysis methods aimed at extracting and exploiting the information contained in spatially distributed patterns of brain activity. These methods will be used to analyze data collected in projects 1, 2 and 3.
  5. It will also provide training and support for all Conte Center participants on how to use the computing facility, its software, data sharing tools, and new data analysis algorithms. The training, as in previous years, will come in the form of an annual tutorial operated in conjunction with the Administrative and Neuroimaging Cores, as well as through day-to-day support.

Overseeing these aims will be a Director (Singer), who has extensive experience in software design and computer hardware. Assisting him will be a Systems Manager (Tengi) who has efficiently fulfilled this role for the last six years. The Center PI (Cohen) will work closely with the Director to facilitate coordination of core activities with those of the other cores, the projects, and in facilitating new collaborations.

Publications

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